Errfi1^tm1Gvw
Targeted Allele Detail

Summary

• Symbol: Errfi1^tm1Gvw
• Name: ERBB receptor feedback inhibitor 1; targeted mutation 1, George F Vande Woude
• MGI ID: MGI:3603195
• Synonyms: Mig-6^-
• Gene: Errfi1 Location: Chr4:150938376-150953349 bp, + strand Genetic Position: Chr4, 81.5 cM, cytoband E1
• Alliance: Errfi1^tm1Gvw page

Errfi1^tm1Gvw/Errfi1^tm1Gvw mouse joints display pathological features of osteoarthritis

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100927
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region (exons 2-4) were replaced with a pgk-neomycin resistance gene. Absence of transcript was demonstrated in Northern blot of mutant liver and thymus. (J:100927)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Errfi1^tm1Gvw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Errfi1 Mutation: 18 strains or lines available

References

• Original: J:100927 Zhang YW, et al., Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11740-5
• All: 5 reference(s)