Socs7^tm1Pbro
Targeted Allele Detail

Summary

• Symbol: Socs7^tm1Pbro
• Name: suppressor of cytokine signaling 7; targeted mutation 1, Paul B Rothman
• MGI ID: MGI:3603205
• Synonyms: Socs7^-
• Gene: Socs7 Location: Chr11:97253261-97289368 bp, + strand Genetic Position: Chr11, 60.96 cM
• Alliance: Socs7^tm1Pbro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100915
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-6 were replaced with a neomycin resistance gene. Disruption of the full length transcript was demonstrated in Northern blot of liver, skeletal muscle and testis. Low levels of expression persisted in the testis, suggesting that the testis-specific isoform is not the product of exons deleted in the targeting event. (J:100915)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Socs7 Mutation: 22 strains or lines available

References

• Original: J:100915 Banks AS, et al., Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J Clin Invest. 2005 Sep;115(9):2462-71
• All: 2 reference(s)