Thra^tm3Ven
Targeted Allele Detail

Summary

• Symbol: Thra^tm3Ven
• Name: thyroid hormone receptor alpha; targeted mutation 3, Bjorn Vennstrom
• MGI ID: MGI:3603303
• Synonyms: Tralpha1R384C, TRalpha^m
• Gene: Thra Location: Chr11:98631539-98659832 bp, + strand Genetic Position: Chr11, 62.58 cM, cytoband D-E
• Alliance: Thra^tm3Ven page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100290
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to introduce an Arg384Cys substitution into helix 12 of the C-terminal region of the encoded protein. (J:100290)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thra Mutation: 40 strains or lines available

References

• Original: J:100290 Tinnikov A, et al., Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1. EMBO J. 2002 Oct 1;21(19):5079-87
• All: 16 reference(s)