Prkca^tm1Cda
Targeted Allele Detail

Summary

• Symbol: Prkca^tm1Cda
• Name: protein kinase C, alpha; targeted mutation 1, Kazuhiro Chida
• MGI ID: MGI:3603307
• Synonyms: Prkca^-
• Gene: Prkca Location: Chr11:107824213-108234754 bp, - strand Genetic Position: Chr11, 70.8 cM
• Alliance: Prkca^tm1Cda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100793
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Cre mediated recombination was used to delete exon 10, which encodes the ATP-binding site essential for enzymatic activity. Absence of protein was confirmed by immunoblot. (J:100793)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkca Mutation: 44 strains or lines available

References

• Original: J:100793 Hara T, et al., Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis. Cancer Res. 2005 Aug 15;65(16):7356-62
• All: 2 reference(s)