Pdx1^tm1Heed
Targeted Allele Detail

Summary

• Symbol: Pdx1^tm1Heed
• Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Helena Edlund
• MGI ID: MGI:3603310
• Gene: Pdx1 Location: Chr5:147206907-147212658 bp, + strand Genetic Position: Chr5, 86.84 cM
• Alliance: Pdx1^tm1Heed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48516
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream and a neo-loxP construct inserted downstream of exon 2A via homologous recombination. (J:48516)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pdx1 Mutation: 35 strains or lines available

References

• Original: J:48516 Ahlgren U, et al., beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev. 1998 Jun 15;12(12):1763-8
• All: 9 reference(s)