Casp7^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Casp7^tm1Flv
• Name: caspase 7; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3603317
• Synonyms: Casp7^-
• Gene: Casp7 Location: Chr19:56385561-56430776 bp, + strand Genetic Position: Chr19, 51.84 cM
• Alliance: Casp7^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59875
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaces exons 2 and 3 with a neomycin resistance cassette, and also results in a frame-shift. Western blot analysis showed absence of caspase 7 expression in homozygous mice. (J:105496)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casp7 Mutation: 17 strains or lines available

References

• Original: J:59875 Zheng TS, et al., Caspase knockouts: matters of life and death. Cell Death Differ. 1999 Nov;6(11):1043-53
• All: 31 reference(s)