Grm8^tm1Duv
Targeted Allele Detail

Summary

• Symbol: Grm8^tm1Duv
• Name: glutamate receptor, metabotropic 8; targeted mutation 1, Robert M Duvoisin
• MGI ID: MGI:3603321
• Synonyms: mGlu8^-, mGluR8^-
• Gene: Grm8 Location: Chr6:27275120-28135094 bp, - strand Genetic Position: Chr6, 11.97 cM, cytoband A3
• Alliance: Grm8^tm1Duv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101087
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 8, which encodes six of the seven predicted transmembrane segments. Both splice variants were undetectable by immunoblot. (J:101087)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm8 Mutation: 68 strains or lines available

References

• Original: J:101087 Duvoisin RM, et al., Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8. Eur J Neurosci. 2005 Jul;22(2):425-36
• All: 8 reference(s)