Neurod1^tm1Kan
Targeted Allele Detail

Summary

• Symbol: Neurod1^tm1Kan
• Name: neurogenic differentiation 1; targeted mutation 1, Klaus-Armin Nave
• MGI ID: MGI:3603334
• Synonyms: Neurod1^f, NeuroD^loxP(neoTk)
• Gene: Neurod1 Location: Chr2:79282981-79286980 bp, - strand Genetic Position: Chr2, 47.58 cM
• Alliance: Neurod1^tm1Kan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101098
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo was inserted into intron 1 and a third loxP site was inserted in the 3' UTR. RT-PCR and Northern blot confirmed aberrant splicing of exon 1 to the neo cassette, creating a nonfunctional allele. (J:101098)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurod1 Mutation: 29 strains or lines available

References

• Original: J:101098 Goebbels S, et al., Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2. Genesis. 2005 Aug;42(4):247-52
• All: 4 reference(s)