Idd25^NOD/ShiLt
QTL Variant Detail

Summary

• QTL variant: Idd25^NOD/ShiLt
• Name: insulin dependent diabetes susceptibility 25; NOD/ShiLt
• MGI ID: MGI:3603353
• QTL: Idd25 Location: unknown Genetic Position: Chr4, cM position of peak correlated region/allele: 66.32 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NOD/ShiLt

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Idd25 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:100365

Linkage analysis was performed on 185 animals from a (NOD/Lt x NOR.NOD-(Il1-D2Mit144)/Lt)F2 intercross to identify new diabetes resistance loci. Parental strain NOD/Lt is susceptible to type 1 diabetes. NOR.NOD-(Il1-D2Mit144) is a diabetes-resistant congenic line carrying NOD/Lt-derived DNA from Il1 (73 cM) to D2Mit144 (97 cM) on a NOR/Lt genetic background. The congenic interval replaces the Idd13 resistance locus with NOD/Lt susceptibility alleles.

Linkage to type 1 diabetes resistance in females mapped to 61.9 cM on mouse Chromosome 4 near D4Mit71 (LOD=5.87). This locus is designated Idd25 (insulin dependent diabetes susceptibility 25) and shows overlap with previously identified diabetes QTLs Idd11 (64.6 cM) and Idd9 (42.6 cM). NOR/Lt-derived alleles at Idd25 confer resistance to type 1 diabetes in females with an additive mode of inheritance.

Diabetes resistance in female animals mapped near D1Mit3 (11 cM, LOD=3.08) and D1Mit232 (20.8 cM, LOD=3.04) on mouse Chromosome 1. Peak linkage is predictedat 24 cM - 35 cM. This locus is named Idd26 (insulin dependent diabetes susceptibility 26) and shows overlap with previously identified diabetes QTL Idd5b (41 cM). NOR/Lt-derived alleles at Idd26 confer resistance to type 1 diabetes in females.

Suggestive linkage to diabetes resistance in females mapped to mouse Chromosome 11 between D11Mit87 (27.5 cM) and SNP 11-064063416N with LOD=2.30-2.34.

References

• Original: J:100365 Reifsnyder PC, et al., Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice. Genes Immun. 2005 Sep;6(6):528-38
• All: 1 reference(s)