Myo1c^tm1Pgg
Targeted Allele Detail

Summary

• Symbol: Myo1c^tm1Pgg
• Name: myosin IC; targeted mutation 1, Peter G Gillespie
• MGI ID: MGI:3603408
• Synonyms: Myo1c^Y61G
• Gene: Myo1c Location: Chr11:75541330-75564736 bp, + strand Genetic Position: Chr11, 45.92 cM, cytoband C-E1
• Alliance: Myo1c^tm1Pgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100987
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A tyrosine to glycine mutation at codon 61 (Y61G) was inserted into the locus. Protein levels in mutant mice were nearly identical to those in wild-type in all tissues examined. Immunoblotting demonstrated that the mutant protein was expressed in the auditory and vestibular systems. (J:100987)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo1c Mutation: 87 strains or lines available

References

• Original: J:100987 Stauffer EA, et al., Fast adaptation in vestibular hair cells requires Myosin-1c activity. Neuron. 2005 Aug 18;47(4):541-53
• All: 1 reference(s)