Epha4^tm6Kln
Targeted Allele Detail

Summary

• Symbol: Epha4^tm6Kln
• Name: Eph receptor A4; targeted mutation 6, Rudiger Klein
• MGI ID: MGI:3603431
• Synonyms: EphA4^EE, Epha4^tm5Kln
• Gene: Epha4 Location: Chr1:77343822-77491725 bp, - strand Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
• Alliance: Epha4^tm6Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101019
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to introduce Y596E/Y602E mutations. Expression levels found in mutants were similar to that of wild-type animals, however, the protein displayed somewhat slower mobility in SDS-PAGE, possibly due to the additional negative charge from the two glutamic acids. (J:101019)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epha4 Mutation: 67 strains or lines available

References

• Original: J:101019 Egea J, et al., Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron. 2005 Aug 18;47(4):515-28
• All: 3 reference(s)