Lrp8^tm2.1Her
Targeted Allele Detail

Summary

• Symbol: Lrp8^tm2.1Her
• Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 2.1, Joachim Herz
• MGI ID: MGI:3603433
• Synonyms: Apoer2[ex19], Apoer2[long], ex19
• Gene: Lrp8 Location: Chr4:107659337-107734037 bp, + strand Genetic Position: Chr4, 50.18 cM, cytoband C7
• Alliance: Lrp8^tm2.1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100988
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: A targeting vector containing exons 17-20 and loxP-flanked neomycin cassette encoding the intracellular domain was inserted into the locus such that the locus constitutively expressed the 59 amino acid insert encoded by exon 19. Cre-mediated recombination removed the neomycin cassette. (J:100988)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp8 Mutation: 43 strains or lines available

References

• Original: J:100988 Beffert U, et al., Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 2005 Aug 18;47(4):567-79
• All: 4 reference(s)