Fmr1^tm1.1Cidz
Targeted Allele Detail

Summary

• Symbol: Fmr1^tm1.1Cidz
• Name: fragile X messenger ribonucleoprotein 1; targeted mutation 1.1, Chris I de Zeeuw
• MGI ID: MGI:3603442
• Synonyms: Fmr1 CKO, Fmr1^cON, Fmr1^loxP, Fmrp-cON
• Gene: Fmr1 Location: ChrX:67722147-67761569 bp, + strand Genetic Position: ChrX, 34.83 cM
• Alliance: Fmr1^tm1.1Cidz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101021
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: The first coding exon was left flanked with loxP sites 2800 bp in front of exon 1 of the gene and and a second loxP site 260 bp after exon 1 in intron 1, upon removal of a floxed neomycin resistance cassette. This allele has some residual endogenous protein expression at either 1.5% or 10% nominal levels. (J:101021, J:108008, J:282335)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmr1 Mutation: 29 strains or lines available

References

• Original: J:101021 Koekkoek SK, et al., Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron. 2005 Aug 4;47(3):339-52
• All: 24 reference(s)