Scd2^tm1Myz
Targeted Allele Detail

Summary

• Symbol: Scd2^tm1Myz
• Name: stearoyl-Coenzyme A desaturase 2; targeted mutation 1, Makoto Miyazaki
• MGI ID: MGI:3603451
• Synonyms: Scd2^-
• Gene: Scd2 Location: Chr19:44282115-44295303 bp, + strand Genetic Position: Chr19, 37.98 cM
• Alliance: Scd2^tm1Myz page

Phenotypic appearance of newborn and adult Scd2^tm1Myz/Scd2^tm1Myz mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101158
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 1-6 of the locus, the entire coding sequence. Expression was absent in mutant brains. (J:101158)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scd2 Mutation: 28 strains or lines available

References

• Original: J:101158 Miyazaki M, et al., Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12501-6
• All: 4 reference(s)