Acaca^tm1Sjw
Targeted Allele Detail

Summary

• Symbol: Acaca^tm1Sjw
• Name: acetyl-Coenzyme A carboxylase alpha; targeted mutation 1, Salih J Wakil
• MGI ID: MGI:3603457
• Synonyms: Acc1^-, Acc1^tm1AL
• Gene: Acaca Location: Chr11:84020498-84292477 bp, + strand Genetic Position: Chr11, 51.29 cM
• Alliance: Acaca^tm1Sjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101150
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two of the exons upstream of the biotin-binding motif were replaced with an HPRT expression cassette. (J:101150)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acaca Mutation: 128 strains or lines available

References

• Original: J:101150 Abu-Elheiga L, et al., Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12011-6
• All: 1 reference(s)