Slc25a12^{Gt(OST123999)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Slc25a12^{Gt(OST123999)Lex}
• Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12; gene trap OST123999, Lexicon Genetics
• MGI ID: MGI:3603462
• Synonyms: Aralar^-, Slc25a12^Gt(neo)1Lex
• Gene: Slc25a12 Location: Chr2:71104614-71198125 bp, - strand Genetic Position: Chr2, 42.38 cM
• Alliance: Slc25a12^{Gt(OST123999)Lex} page

Mutation origin

• Mutant Cell Line: OST123999
• Germline Transmission: Earliest citation of germline transmission: J:101164
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a splice acceptor site and a BTK-neo was inserted into intron 13. Northern blot detected a fusion transcript between the 5' endogenous locus and the neo. Western blot demonstrated lack of endogenous protein in mutants. (J:101164)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST123999	CG536256 ; (MGI Seq Detail)	3' RACE	Chr2:71106775-71113226 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  80 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a12 Mutation: 103 strains or lines available

References

• Original: J:101164 Jalil MA, et al., Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. J Biol Chem. 2005 Sep 2;280(35):31333-9
• All: 15 reference(s)