Frem2^my-F11
Chemically induced Allele Detail

Summary

• Symbol: Frem2^my-F11
• Name: Fras1 related extracellular matrix protein 2; my-F11
• MGI ID: MGI:3603530
• Synonyms: my^F11
• Gene: Frem2 Location: Chr3:53421359-53564776 bp, - strand Genetic Position: Chr3, 25.24 cM
• Alliance: Frem2^my-F11 page

Blistering and hemorrhages in Frem2^my-F11/Frem2^my-F11 embryos and mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: These mutants have a C to A transversion that generates a stop codon and produces a truncated protein of 1,880 amino acids out of the normal 3,100, and lacking four of the five CALXbeta motifs. If a truncated protein would be produced, the loss of several conserved regions suggests that nay product would have limited function. (J:101189)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frem2 Mutation: 137 strains or lines available

References

• Original: J:101189 Timmer JR, et al., Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11746-50
• All: 2 reference(s)