Lhx8^tm1Vpa
Targeted Allele Detail

Summary

• Symbol: Lhx8^tm1Vpa
• Name: LIM homeobox protein 8; targeted mutation 1, Vassilis Pachnis
• MGI ID: MGI:3603531
• Synonyms: Lhx7^nLacZ, Lhx8^tm1Pach
• Gene: Lhx8 Location: Chr3:154011925-154036190 bp, - strand Genetic Position: Chr3, 79.12 cM, cytoband H3-H4
• Alliance: Lhx8^tm1Vpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exons 3-5 were replaced with a lacZ reporter. The deleted region encodes the two LIM domains and part of the homeodomain. Expression of the mutant allele was shown in the maxillary and mandibular processes of the first branchial arch, the pinna, and the medial ganglionic eminence of the telencephalon, corresponding to expression of the endogenous locus. (J:101205)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx8 Mutation: 25 strains or lines available

References

• Original: J:101205 Fragkouli A, et al., Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur J Neurosci. 2005 Jun;21(11):2923-38
• All: 6 reference(s)