Dido1^tm1Cmar
Targeted Allele Detail

Summary

• Symbol: Dido1^tm1Cmar
• Name: death inducer-obliterator 1; targeted mutation 1, Carlos Martinez-A
• MGI ID: MGI:3603539
• Synonyms: Dido3deltaNT, Dido^neo
• Gene: Dido1 Location: Chr2:180299757-180351792 bp, - strand Genetic Position: Chr2, Syntenic
• Alliance: Dido1^tm1Cmar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101201
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace exon IV and most of exon III with a neomycin resistance cassette. Mutant cells lacked isoforms 1 and 2, but retained a short transcript for isoform 3. This transcript lacked exons III and IV, indicating that the original translation start signal was absent. The short protein had to be initiated at an ATG codon in exon V or a downstream codon. (J:101201)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dido1 Mutation: 186 strains or lines available

References

• Original: J:101201 Futterer A, et al., Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms. J Clin Invest. 2005 Sep 1;115(9):2351-2362
• All: 4 reference(s)