Smarcb1^tm1Gvk
Targeted Allele Detail

Summary

• Symbol: Smarcb1^tm1Gvk
• Name: SWI/SNF related BAF chromatin remodeling complex subunit B1; targeted mutation 1, Ganjam V Kalpana
• MGI ID: MGI:3603561
• Synonyms: Ini1^delta6,7
• Gene: Smarcb1 Location: Chr10:75732603-75757448 bp, - strand Genetic Position: Chr10, 38.61 cM
• Alliance: Smarcb1^tm1Gvk page

Smarcb1^tm1Gvk/Smarcb1⁺ mice develop tumors that overexpress Cyclin D1

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101185
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 and 7 were replaced with a PGK-hygromycin resistance cassette. Immunoblot of total protein from heterozygous mice failed to detect a truncated protein corresponding to the mutant allele, thereby indicating it is most likely a null. (J:101185)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smarcb1 Mutation: 22 strains or lines available

References

• Original: J:101185 Tsikitis M, et al., Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12129-34
• All: 2 reference(s)