Bace1^tm2Psa
Targeted Allele Detail

Summary

• Symbol: Bace1^tm2Psa
• Name: beta-site APP cleaving enzyme 1; targeted mutation 2, Paul Saftig
• MGI ID: MGI:3603597
• Synonyms: BACE1II
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm2Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100925
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination removed exon 2 from the locus. Expression was abolished in brain, liver and kidney as shown by quantitative RT-PCR. (J:100925)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 30 strains or lines available

References

• Original: J:100925 Dominguez D, et al., Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem. 2005 Sep 2;280(35):30797-806
• All: 1 reference(s)