Sstr5^tm1Hawi
Targeted Allele Detail

Summary

• Symbol: Sstr5^tm1Hawi
• Name: somatostatin receptor 5; targeted mutation 1, Hilary A Wilkinson
• MGI ID: MGI:3603655
• Gene: Sstr5 Location: Chr17:25708849-25716262 bp, - strand Genetic Position: Chr17, 12.62 cM
• Alliance: Sstr5^tm1Hawi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101259
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single coding exon was replaced with neo and lacZ genes. Expression of lacZ was detected in the brain. RT-PCR confirmed the absence of RNA expression in the pancreas, endocrine islets, brain, and adipose tissue. (J:101259)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sstr5 Mutation: 14 strains or lines available

References

• Original: J:101259 Strowski MZ, et al., Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Mol Endocrinol. 2003 Jan;17(1):93-106
• All: 1 reference(s)