Erbb4^tm1Htig
Targeted Allele Detail

Summary

• Symbol: Erbb4^tm1Htig
• Name: erb-b2 receptor tyrosine kinase 4; targeted mutation 1, Cecilia M Hertig
• MGI ID: MGI:3603749
• Synonyms: erb-b4^F, ErbB4^loxP
• Gene: Erbb4 Location: Chr1:68071345-69147218 bp, - strand Genetic Position: Chr1, 33.8 cM
• Alliance: Erbb4^tm1Htig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101252
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector was designed such that exon 2 was flanked with loxP sites and an FRT-flanked neomycin resistance gene was inserted into intron 2. No difference was found between mRNA expression levels or patterns in hearts of mutant mice compared to wild-type. (J:101252)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb4 Mutation: 87 strains or lines available

References

• Original: J:101252 Garcia-Rivello H, et al., Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1153-60
• All: 20 reference(s)