Pcd4ts1^DBA/2
QTL Variant Detail

Summary

• QTL variant: Pcd4ts1^DBA/2
• Name: p-glycoprotein positive CD4 T cell subset 1; DBA/2
• MGI ID: MGI:3603789
• QTL: Pcd4ts1 Location: Chr6:34711598-34711719 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 15.12 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased proportion of P-glycoprotein positive CD4 T cells in 18 month old mated mice compared to C3H. (J:83220)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83220

Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with P-glycoprotein positive CD4 T cell subsetlevels, Pcd4ts1, mapped to 15.6 cM (D6Mit268) on mouse Chromosome 6 with statistical significance of P<0.05. Pcd4ts1 is associated with P-glycoprotein positive CD4 T cell levels in 18 month old mated mice.

References

• Original: J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
• All: 1 reference(s)