Grm1^tm1Kyo
Targeted Allele Detail

Summary

• Symbol: Grm1^tm1Kyo
• Name: glutamate receptor, metabotropic 1; targeted mutation 1, Tadao Serikawa
• MGI ID: MGI:3604007
• Synonyms: Grm1^tm1Nak, mGluR1 D854T
• Gene: Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
• Alliance: Grm1^tm1Kyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101301
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The D854T mutation was inserted into the exon encoding the 7 transmembrane domain. Transient expression of cre recombinase removed a floxed neo included in the targeting vector. Expression of RNA in mutant cerebellum was similar to wild-type. Protein expression in mutants was normal. (J:101301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Grm1 Mutation: 81 strains or lines available

References

• Original: J:101301 Sato M, et al., Altered agonist sensitivity and desensitization of neuronal mGluR1 responses in knock-in mice by a single amino acid substitution at the PKC phosphorylation site. Eur J Neurosci. 2004 Aug;20(4):947-55
• All: 1 reference(s)