Tg(Plp1-SNCA)1Haa
Transgene Detail

Summary

• Symbol: Tg(Plp1-SNCA)1Haa
• Name: transgene insertion 1, Christian Haass
• MGI ID: MGI:3604008
• Transgene: Tg(Plp1-SNCA)1Haa Location: unknown
• Alliance: Tg(Plp1-SNCA)1Haa page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Plp1-SNCA)1Haa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The proteolipid protein promoter was used to drive human wild-type alpha synuclein expression. Transgenic protein was detected in oligodendrocytes but in no other brain cell type. Lines 5, 25 and 27 were also created. (J:100960)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100960 Kahle PJ, et al., Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Rep. 2002 Jun;3(6):583-8
• All: 8 reference(s)