Tg(Prdx6)153Pgn
Transgene Detail

Summary

• Symbol: Tg(Prdx6)153Pgn
• Name: transgene insertion 153, Beverly J Paigen
• MGI ID: MGI:3604080
• Synonyms: Prdx6^129/SvJ-Tg
• Transgene: Tg(Prdx6)153Pgn Location: unknown
• Alliance: Tg(Prdx6)153Pgn page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prdx6)153Pgn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prdx6 (MGI:894320)

• Mutation details: The transgene consists of the entire Prdx6 sequence (approximately 10 kB) and 6.6 kB of upstream sequence from the diet-induced atherosclerosis resistant 129X1/SvJ mouse strain. The 129X1/SvJ sequence contains an amino acid variant at position 124 encoding aspartic acid rather than the alanine found in C57BL/6. Southern blot analysis distinguishes between endogenous and transgenic genes. Lines 153 and 105 contained multiple copies of the transgene and were selected for further analysis. Western blot, ELISA and immunohistochemical analysis reveal higher levels of PRDX6 expression in many tissues, especially liver and aorta, than is found in tissues normally expressing the gene. (J:86528)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:86528 Phelan SA, et al., Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root. Free Radic Biol Med. 2003 Nov 1;35(9):1110-20
• All: 18 reference(s)