Tg(Prnp-MAPT)25Hlmc
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT)25Hlmc
• Name: transgene insertion 25, Mike Hutton
• MGI ID: MGI:3604150
• Synonyms: JN25
• Transgene: Tg(Prnp-MAPT)25Hlmc Location: unknown
• Alliance: Tg(Prnp-MAPT)25Hlmc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-MAPT)25Hlmc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The mouse prion protein promoter was used to drive expression of human microtubule-associated protein tau cDNA with exon 10, but lacking exons 2 and 3. These exons encode four-repeat tau without amino-terminal inserts. Hemizygous mice expressed the transgene at levels roughly equivalent to that of endogenous tau. (J:63887)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Microinjected into fertilized mouse C57BL/DBA2/SW eggs.

References

• Original: J:63887 Lewis J, et al., Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet. 2000 Aug;25(4):402-5
• All: 2 reference(s)