Hey1^tm2Gess
Targeted Allele Detail

Summary

• Symbol: Hey1^tm2Gess
• Name: hairy/enhancer-of-split related with YRPW motif 1; targeted mutation 2, Manfred Gessler
• MGI ID: MGI:3604208
• Synonyms: Hey1^fl
• Gene: Hey1 Location: Chr3:8728419-8732098 bp, - strand Genetic Position: Chr3, 2.15 cM
• Alliance: Hey1^tm2Gess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101349
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to flank exons 2-4 with loxP sites. RT-PCR detected mRNA as in wild-type ES cells. (J:101349)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hey1 Mutation: 17 strains or lines available

References

• Original: J:101349 Fischer A, et al., Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol. 2005 Oct;25(20):8960-70
• All: 3 reference(s)