Npm1^{Gt(VICTR37)704Lex}
Gene trapped Allele Detail

Summary

• Symbol: Npm1^{Gt(VICTR37)704Lex}
• Name: nucleophosmin 1; gene trap 704, Lexicon Genetics
• MGI ID: MGI:3604210
• Synonyms: NPM^-, Npm1^{Gt(VICTR37)1Lex}
• Gene: Npm1 Location: Chr11:33102287-33113206 bp, - strand Genetic Position: Chr11, 19.21 cM
• Alliance: Npm1^{Gt(VICTR37)704Lex} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101353
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The VICTR37 gene trap vector containing an IRES-Betageo cassette integrated into intron 1. Western blot failed to detect protein in mutant whole embryo lysates. (J:101353)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npm1 Mutation: 36 strains or lines available

References

• Original: J:101353 Colombo E, et al., Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol. 2005 Oct;25(20):8874-86
• All: 1 reference(s)