Foxe3^tm1Mjam
Targeted Allele Detail

Summary

• Symbol: Foxe3^tm1Mjam
• Name: forkhead box E3; targeted mutation 1, Milan Jamrich
• MGI ID: MGI:3604211
• Synonyms: Foxe3^-
• Gene: Foxe3 Location: Chr4:114782344-114783210 bp, - strand Genetic Position: Chr4, 52.73 cM, cytoband C7
• Alliance: Foxe3^tm1Mjam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101355
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-loxP-neo-containing cassette replaced the entire coding region of the locus. In situ hybridization showed that developing lenses of mutants lacked mRNA. (J:101355)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxe3 Mutation: 15 strains or lines available

References

• Original: J:101355 Medina-Martinez O, et al., Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol Cell Biol. 2005 Oct;25(20):8854-63
• All: 3 reference(s)