Rr148^tm1.1Fwa
Targeted Allele Detail

Summary

• Symbol: Rr148^tm1.1Fwa
• Name: regulatory region 148; targeted mutation 1.1, Frederick W Alt
• MGI ID: MGI:3604300
• Synonyms: cEmu^delta, Igh^tm1.1Fwa
• Gene: Rr148 Location: Chr12:113391013-113391258 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr148^tm1.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101400
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Rr148^tm1.1Fwa involves 1 genes/genome features (Igh) View all
• Mutation details: Cre-mediated excision was used to remove the loxP site flanked neomycin resistance gene cassette that replaced the core Emu enhancer, located between the Igh J and Cmu gene segments. These mice had reduced B cell numbers in association with impaired D to JH and VH to DJH rearrangement. (J:101400)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr148 Mutation: 0 strains or lines available

References

• Original: J:101400 Perlot T, et al., Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14362-7
• All: 6 reference(s)