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Rr148tm1.1Fwa
Targeted Allele Detail
Summary
Symbol: Rr148tm1.1Fwa
Name: regulatory region 148; targeted mutation 1.1, Frederick W Alt
MGI ID: MGI:3604300
Synonyms: cEmudelta, Ightm1.1Fwa
Gene: Rr148  Location: unknown  Genetic Position: Chr12, Syntenic
Alliance: Rr148tm1.1Fwa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101400
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Rr148tm1.1Fwa involves 1 genes/genome features (Igh) View all
 
Mutation detailsCre-mediated excision was used to remove the loxP site flanked neomycin resistance gene cassette that replaced the core Emu enhancer, located between the Igh J and Cmu gene segments. These mice had reduced B cell numbers in association with impaired D to JH and VH to DJH rearrangement. (J:101400)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr148 Mutation:  0 strains or lines available
References
Original:  J:101400 Perlot T, et al., Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14362-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory