Slc8a1^tm1Kdp
Targeted Allele Detail

Summary

• Symbol: Slc8a1^tm1Kdp
• Name: solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 1, Kenneth D Philipson
• MGI ID: MGI:3604379
• Synonyms: NCX1^fx
• Gene: Slc8a1 Location: Chr17:81680534-82045806 bp, - strand Genetic Position: Chr17, 51.29 cM
• Alliance: Slc8a1^tm1Kdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101484
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 11, which encodes amino acids 722-813. These amino acids encompass two transmembrane segments including part of the alpha-2 region essential for exchange activity. (J:101484)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc8a1 Mutation: 55 strains or lines available

References

• Original: J:101484 Henderson SA, et al., Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circ Res. 2004 Sep 17;95(6):604-11
• All: 21 reference(s)