Gng7^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Gng7^tm1Lex
• Name: guanine nucleotide binding protein (G protein), gamma 7; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3604392
• Synonyms: Gng7^-, Gng7^tm1Rbs
• Gene: Gng7 Location: Chr10:80784463-80850742 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gng7^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81988
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: Coding exons 1 and 2 were targeted by homologous recombination. Neither transcript nor protein was detected in homozygous mutant brain tissue by RT-PCR and Western blot analyses. (J:81988, J:103485)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Gng7 Mutation: 75 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:81988 Schwindinger WF, et al., Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production. J Biol Chem. 2003 Feb 21;278(8):6575-9
• All: 4 reference(s)