Cxcr3^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Cxcr3^tm1Dgen
• Name: C-X-C motif chemokine receptor 3; targeted mutation 1, Deltagen
• MGI ID: MGI:3604545
• Gene: Cxcr3 Location: ChrX:100775141-100777753 bp, - strand Genetic Position: ChrX, 44.58 cM
• Alliance: Cxcr3^tm1Dgen page

Mutation origin

• Mutant Cell Line: 2697
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in spleen, lymph nodes and ovary, moderate levels in cerebellum, lung, liver, pancreas, kidney, thymus, bone marrow, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, colon, epididymis, seminal vesicle, coagulating gland, uterus and white fat, and low levels in whole brain, cortex, subcortical region, brainstem, olfactory bulb, spinal cord, eye, Harderian glands, heart, skeletal muscle, tongue, stomach, small intestine, cecum, testis and prostate gland. However, faint beta-galactosidase expression from this allele is detectable in only in whole mount brain.

Expression

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcr3 Mutation: 14 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 76 reference(s)