Drd5^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Drd5^tm1Dgen
• Name: dopamine receptor D5; targeted mutation 1, Deltagen
• MGI ID: MGI:3604549
• Gene: Drd5 Location: Chr5:38476742-38479868 bp, + strand Genetic Position: Chr5, 20.4 cM
• Alliance: Drd5^tm1Dgen page

Mutation origin

• Mutant Cell Line: 1853
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in whole brain, cortex, subcortical region, brainstem, olfactory bulb, spinal cord, eye, spleen and testis and low levels in cerebellum, thymus, skin, urinary bladder, pituitary gland, epididymis, coagulating gland, prostate gland, and white fat. However, beta-galactosidase expression from this allele is faintly detectable in only in a few follicles in the ovary. (J:101679)

Expression

In Mice Carrying this Mutation:

50 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd5 Mutation: 39 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 2 reference(s)