S1pr4^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: S1pr4^tm1Dgen
• Name: sphingosine-1-phosphate receptor 4; targeted mutation 1, Deltagen
• MGI ID: MGI:3604550
• Gene: S1pr4 Location: Chr10:81333581-81335966 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: S1pr4^tm1Dgen page

Mutation origin

• Mutant Cell Line: 3620
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in spleen and lymph nodes, moderate levels in lung, thymus, bone marrow, gallbladder, pituitary gland, uterus and white fat and low levels in brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, Harderian glands, heart, liver, kidney, skin, urinary bladder, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, coagulating gland, prostate gland and ovaries. However, beta-galactosidase expression from this allele is detectable only in testis with strong staining in several spermatogenic cells in the seminiferous tubules of testis.

Expression

In Mice Carrying this Mutation:

38 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S1pr4 Mutation: 20 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 4 reference(s)