Efemp2^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Efemp2^tm1Dgen
• Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 2; targeted mutation 1, Deltagen
• MGI ID: MGI:3604551
• Synonyms: Fbln4^-, fibulin-4^-
• Gene: Efemp2 Location: Chr19:5523982-5532545 bp, + strand Genetic Position: Chr19, 4.33 cM, cytoband A
• Alliance: Efemp2^tm1Dgen page

Efemp2^tm1Dgen/Efemp2⁺ mice exhibit abnormal aorta morphology

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 2561
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in all tissues tested, strong beta-galactosidase expression from this allele is detectable in brain, spinal cord, eyes, Harderian glands, thymus, spleen, lymph nodes, aorta, heart, lung, liver, gallbladder, pancreas, kidney, urinary bladder, trachea, larynx, esophagus, thyroid gland, pituitary gland, adrenal glands, salivary glands, tongue, skeletal muscle, skin, male and female reproductive systems. In many tissues lacZ is expressed in smooth muscle cells.

Expression

In Mice Carrying this Mutation:	123 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Efemp2 Mutation: 26 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 8 reference(s)