Tgfbr1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Tgfbr1^tm1Dgen
• Name: transforming growth factor, beta receptor I; targeted mutation 1, Deltagen
• MGI ID: MGI:3604556
• Gene: Tgfbr1 Location: Chr4:47353258-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
• Alliance: Tgfbr1^tm1Dgen page

Mutation origin

• Mutant Cell Line: 4398
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in most tissues analyzed, beta-galactosidase expression from this allele is detectable in all organs examined, with most striking expression in aorta and other blood vessels, heart valve, renal papilla, muscularis of the urinary bladder, corpus lutea in the ovary and in testis.

Expression

In Mice Carrying this Mutation:

129 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tgfbr1 Mutation: 36 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 3 reference(s)