Slc22a6^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Slc22a6^tm1Dgen
• Name: solute carrier family 22 (organic anion transporter), member 6; targeted mutation 1, Deltagen
• MGI ID: MGI:3604571
• Synonyms: Oat1^-
• Gene: Slc22a6 Location: Chr19:8595403-8605663 bp, + strand Genetic Position: Chr19, 5.44 cM
• Alliance: Slc22a6^tm1Dgen page

Mutation origin

• Mutant Cell Line: 3797
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A bacterial lacZ gene and neomycin resistance cassette was inserted to replace a 52 bp segment within the coding portion of exon 1 such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects high levels of RNA transcripts in the kidney and very low levels in the brain, beta-galactosidase expression from this allele is detectable in brain and kidney. (J:108655)

Expression

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc22a6 Mutation: 34 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 15 reference(s)