Scn11a^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Scn11a^tm1Dgen
• Name: sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, Deltagen
• MGI ID: MGI:3604572
• Synonyms: Nav1.9^-, SCN11A^-
• Gene: Scn11a Location: Chr9:119582829-119654522 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
• Alliance: Scn11a^tm1Dgen page

Mutation origin

• Mutant Cell Line: 3268
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-neo cassette was inserted to replace 174 bp encompassing exon 3 and parts of exons 2 and 4, and encoding the first and second membrane-spanning segments of domain I. While RT-PCR analysis detects a gene transcript in most tissues analyzed, beta-galactosidase expression from this allele is not detectable in any tissues or organs. (J:99870)

Expression

In Mice Carrying this Mutation:

51 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn11a Mutation: 88 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 4 reference(s)