Scn9a^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Scn9a^tm1Dgen
• Name: sodium channel, voltage-gated, type IX, alpha; targeted mutation 1, Deltagen
• MGI ID: MGI:3604573
• Synonyms: Scn9a^tm10gen
• Gene: Scn9a Location: Chr2:66310424-66465306 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn9a^tm1Dgen page

Mutation origin

• Mutant Cell Line: 4129
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in many of the tissues analyzed except for lung, liver, kidney, bone marrow, and uterus, beta-galactosidase expression from this allele is detectable in brain, urinary bladder, trachea, larynx, pharynx, tongue, male reproductive system and neuronal ganglia.

Expression

In Mice Carrying this Mutation:	56 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn9a Mutation: 121 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 2 reference(s)