Gpr6tm1Dgen
Targeted Allele Detail
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Symbol: |
Gpr6tm1Dgen |
Name: |
G protein-coupled receptor 6; targeted mutation 1, Deltagen |
MGI ID: |
MGI:3604582 |
Gene: |
Gpr6 Location: Chr10:40945973-40948281 bp, - strand Genetic Position: Chr10, 22.08 cM
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Alliance: |
Gpr6tm1Dgen page
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Mutant Cell Line: |
6421 |
Germline Transmission: |
Earliest citation of germline transmission:
J:101679
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Project Collection: |
Deltagen
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Disruption caused by insertion of vector
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Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the whole brain, cortex, subcortical region, pancreas, pituitary gland and adrenal gland, moderate levels in cerebellum, olfactory bulb, eye, heart, liver, thymus, lymph nodes, skin, salivary gland, large intestine and prostate gland and low levels in kidney, spleen, testis and seminal vesicle. Beta-galactosidase expression from this allele is detectable in brain, eyes and pituitary gland. Strong expression was detected in several regions of the brain, including the caudate putamen, cortex, thalamus and hippocampus. Moderate expression was detected in some cells in the inner nuclear layer of the retina. In the pituitary gland, moderate staining was observed in many cells of the pars intermedia.
(J:101679)
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View phenotypes and curated references for all genotypes (concatenated display).
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See also, data as provided by Deltagen, Inc.
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Original: |
J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005; |
All: |
4 reference(s) |
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