Grk5^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Grk5^tm1Dgen
• Name: G protein-coupled receptor kinase 5; targeted mutation 1, Deltagen
• MGI ID: MGI:3604583
• Gene: Grk5 Location: Chr19:60878187-61084406 bp, + strand Genetic Position: Chr19, 56.52 cM
• Alliance: Grk5^tm1Dgen page

Mutation origin

• Mutant Cell Line: 6394
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects gene transcript in all tissues tested. Beta-galactosidase expression from this allele is detectable in most tissues examined. Strongest staining was observed in the central nervous system, spleen, heart, lung and larynx. Staining was observed in different tissue and cell types, including smooth, cardiac and skeletal muscle, neurons, epithelium, cartilage, lymphatic tissue, adipose tissue and blood vessels.

Expression

In Mice Carrying this Mutation:

116 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grk5 Mutation: 44 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 1 reference(s)