Ptch2^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Ptch2^tm1Dgen
• Name: patched 2; targeted mutation 1, Deltagen
• MGI ID: MGI:3604587
• Gene: Ptch2 Location: Chr4:116953272-116973298 bp, + strand Genetic Position: Chr4, 53.41 cM, cytoband C-D
• Alliance: Ptch2^tm1Dgen page

Mutation origin

• Mutant Cell Line: 5341
• Germline Transmission: Earliest citation of germline transmission: J:101679
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis on samples from heterozygous mice detects a gene transcript at high levels in testis and at lower levels in skin, urinary bladder, pituitary gland, adrenal gland, epididymis, coagulating gland, white fat, and most othe tissues examined; beta-galactosidase expression is detectable in brain, spinal cord, sciatic nerve, aorta, heart, lung, liver, pancreas, kidney, urinary bladder, thyroid gland, trachea, pituitary gland, adrenal glands, skeletal muscle, skin, testis, prostate gland, ovary, uterus and cervix.

Expression

In Mice Carrying this Mutation:	58 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptch2 Mutation: 47 strains or lines available

Notes

See also, data as provided by Deltagen, Inc.

References

• Original: J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005
• All: 3 reference(s)