G3bp1^tm1Tazi
Targeted Allele Detail

Summary

• Symbol: G3bp1^tm1Tazi
• Name: G3BP stress granule assembly factor 1; targeted mutation 1, Jamal Tazi
• MGI ID: MGI:3604716
• Synonyms: G3BP^-
• Gene: G3bp1 Location: Chr11:55360521-55391722 bp, + strand Genetic Position: Chr11, 33.09 cM
• Alliance: G3bp1^tm1Tazi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101358
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The locus was disrupted by the insertion of a promoterless beta-geo cassette into exon 2 at the ATG. Sequence from exons 2 and 3 were removed. Western blot confirmed successful ablation of the endogenous protein, and successful expression of betagal in mutant embryos. (J:101358)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any G3bp1 Mutation: 73 strains or lines available

References

• Original: J:101358 Zekri L, et al., Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP. Mol Cell Biol. 2005 Oct;25(19):8703-16
• All: 4 reference(s)