Mlepq1^M16
QTL Variant Detail

Summary

• QTL variant: Mlepq1^M16
• Name: M16 leptin QTL 1; M16
• MGI ID: MGI:3604762
• QTL: Mlepq1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: M16

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased plasma leptin compared to ICR. (J:101200)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:101200

Linkage analysis was performed on 1181 animals from a (ICR x M16)F2 intercross to identify QTL associated with growth and energy balance traits. The M16 parental is a long term selection line exhibiting increased body size, increased weight, increased fat, hyperphagia, and diabetes compared to parental strain ICR. 80 microsatellite markers at an average spacing of 20 cM were used in the genome scan. F2 animals were phenotyped for body weight at time intervals between 3-8 weeks of age and between 4-8 weeks for feed intake. Blood glucose measurements were taken at 8 weeks.

Significantly linkage to feed intake (adjusted for body weight) mapped to 57 cM (112.9 Mb) on mouse Chromosome 1 with LOD=3.4. This locus is named Mfiq5 (M16 feed intake QTL 5) and explains 1.8% of the residual variance. M16-derived alleles at Mfiq5 confer increased feed intake. The Mfiq5 confidence interval spans 34 cM - 103 cM. Suggestive linkage to feed intake mapped to 21 cM with LOD=2.9 with M16-derived alleles conferring decreased feed intake.

Linkage to plasma leptin mapped to 93 cM (141.4 Mb) on mouse Chromosome 2 with LOD=7.7. This locus is named Mlepq1 (M16 leptin QTL 1) and explains 5.7% of the residual variance. Mlepq1 also shows linkage to plasma leptin adjusted for body fat (LOD=3.7). The confidence interval for Mlepq1 spans 83 cM - 104 cM. M16-derived alleles at Mlepq1 confer decreased plasma leptin. Suggestive linkage to plasma insulin mapped to 100 cM (LOD=3.2) with M16-derived alleles conferring increased plasma insulin levels.

Linkage to feed efficiency at week 5 mapped to 54 cM (94.7 MB) on mouse Chromosome 8 with LOD=3.7. This locus is named Mfe5q1 (M16 feed efficiency at 5 weeks QTL 1) and explains 2.3% of the residual variance. The confidence interval of Mfe5q1spans 1 cM - 81 cM. M16-derived alleles at Mfe5q1 confer decreased feed efficiency.

Mfiq3 (M16 feed intake QTL 3) mapped to 7 cM (28.5 Mb) on mouse Chromosome 9 with LOD=3.7. This locus explains 2% of the residual variance, and the confidence interval for Mfiq3 spans 7 cM - 60 cM. M16-derived alleles at Mfiq3 confer decreased feed intake. Mfi5q1 (M16 feed intake at 5 weeks QTL 1) mapped to 60 cM (99 Mb) on mouse Chromosome 9. This locus explains 2.3% of the residual variance. The confidence interval ofMfi5q1 spans 7 cM - 60 cM. M16-derived alleles at Mfi5q1 confer decreased feed intake at 5 weeks.

Linkage to feed intake at 7 weeks mapped to 29 cM (47.5 Mb) on mouse Chromosome 11 with LOD=5.3. This locus is named Mfi7q1 (M16 feed intake at 7 weeks QTL1) and explains 2.4% of the residual variance. The confidence interval of Mfi7q1 spans 15 cM - 74 cM. M16-derived alleles at Mfi7q1 confer decreased feed intake at 7 weeks. Feed intake and feed intake at 8 weeks mapped to 33 cM (54.8 Mb) with LOD=8.1 andthis locus is named Mfiq1 (M16 feed intake QTL 1). This locus explains 4.7% of the residual variance and the confidence interval of Mfiq1 interval spans 22 cM - 86 cM. M16-derived alleles at Mfiq1 confer decreased feed intake. Feed efficiency and feed efficiency at 5 weeks mapped to 45 cM (63.5 Mb) on mouse Chromosome 11 with LOD=4.9. This locus is named Mfeq1 (M16 feed efficiency QTL 1) and explains 3% of the residual variance. The confidence interval of Mfeq1 spans 18 cM - 73 cM. M16-derived alleles atMfeq1 confer increased feed efficiency. Linkage to plasma glucose mapped to 60 cM (96.3 cM) with LOD=5.3. This locus is named Mglcq1 (M16 glucose QTL 1) and explains 1.9% of the residual variance. The confidence interval of Mglcq1 spans 58 cM - 86 cM. M16-derived alleles at Mglcq1 confer increased plasma glucose. Suggestive linkage to plasma insulin mapped to 28 cM (46 Mb) with LOD=3. M16-derived alleles confer increased plasma insulin at this locus.

Linkage to feed intake adjusted for body weight mapped to 35 cM (60.6 Mb) on mouse Chromosome 12 with LOD=3.7. This locus is named Mfiq4 (M16 feed intake QTL 4) and explains 2% of the residual variance. The confidence interval of Mfiq4 spans 17 cM - 63 cM. M16-derived alleles at Mfiq4 confer decreased feed intake.

Linkage to feed intake adjusted for body weight mapped to 54 cM (107.5 Mb) on mouse Chromosome 13 with LOD=4.4. This locus is named Mfiq2 (M16 feed intake QTL 2) and explains 2.4% of the residual variance. The confidence interval of Mfiq2 spans 26 cM - 54 cM. M16-derived alleles at Mfiq2 confer decreased feed intake.

Suggestive linkage to plasma glucose mapped to 42 cM (96.3 cM) on mouse Chromosome 15 with LOD=3.1. Increased plasma glucose is conferred by M16-derived alleles.

Linkage to plasma leptin mapped to 52 cM (40.2 Mb) on mouse Chromosome 17 with LOD=3.4. This locus is named Mlepq2 (M16 leptin QTL 2) and explains 2.3% of the residual variance. The confidence interval of Mlepq2 spans 15 cM - 68 cM. Increased plasma leptin is conferred by M16-derived alleles at Mlepq2. Suggestive linkage to plasma insulin mapped to 55 cM (44.3 Mb) with M16-derived alleles conferring increased plasma insulin (LOD=2.9).

References

• Original: J:101200 Allan MF, et al., Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice. Genetics. 2005 Aug;170(4):1863-77
• All: 1 reference(s)