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Npm1tm2Ppp
Targeted Allele Detail
Summary
Symbol: Npm1tm2Ppp
Name: nucleophosmin 1; targeted mutation 2, Pier Paolo Pandolfi
MGI ID: MGI:3604808
Synonyms: Npmhyp
Gene: Npm1  Location: Chr11:33102287-33113206 bp, - strand  Genetic Position: Chr11, 19.21 cM
Alliance: Npm1tm2Ppp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101494
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsAn Frt-flanked neomycin resistance cassette was inserted into intron 6. Mutant mice expressed protein at levels reduced to about 10-30% of wild-type levels. LoxP sites were inserted to flank exons 1 to 6, encompassing the inserted neo. (J:101494)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129S1/Sv * C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
cardiovascular system
abnormal vitelline vasculature morphology
cellular
decreased fibroblast proliferation
chromosome breakage
embryo
abnormal vitelline vasculature morphology
decreased embryo size
abnormal embryonic hematopoiesis
growth/size/body
decreased embryo size
hematopoietic system
abnormal embryonic hematopoiesis
anemia
integument
pallor
mortality/aging
lethality throughout fetal growth and development, complete penetrance
nervous system
abnormal forebrain development
vision/eye
abnormal eye development
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npm1 Mutation:  36 strains or lines available
References
Original:  J:101494 Grisendi S, et al., Role of nucleophosmin in embryonic development and tumorigenesis. Nature. 2005 Sep 1;437(7055):147-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory

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