Npm1^tm2Ppp
Targeted Allele Detail

Summary

• Symbol: Npm1^tm2Ppp
• Name: nucleophosmin 1; targeted mutation 2, Pier Paolo Pandolfi
• MGI ID: MGI:3604808
• Synonyms: Npm^hyp
• Gene: Npm1 Location: Chr11:33102287-33113206 bp, - strand Genetic Position: Chr11, 19.21 cM
• Alliance: Npm1^tm2Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101494
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: An Frt-flanked neomycin resistance cassette was inserted into intron 6. Mutant mice expressed protein at levels reduced to about 10-30% of wild-type levels. LoxP sites were inserted to flank exons 1 to 6, encompassing the inserted neo. (J:101494)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Npm1^tm2Ppp/Npm1^tm2Ppp	involves: 129S1/Sv * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cardiovascular system	√
abnormal vitelline vasculature morphology	√
cellular	√
decreased fibroblast proliferation	√
chromosome breakage	√
embryo	√
abnormal vitelline vasculature morphology	√
decreased embryo size	√
abnormal embryonic hematopoiesis	√
growth/size/body	√
decreased embryo size	√
hematopoietic system	√
abnormal embryonic hematopoiesis	√
anemia	√
integument	√
pallor	√
mortality/aging	√
lethality throughout fetal growth and development, complete penetrance	√
nervous system	√
abnormal forebrain development	√
vision/eye	√
abnormal eye development	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npm1 Mutation: 36 strains or lines available

References

• Original: J:101494 Grisendi S, et al., Role of nucleophosmin in embryonic development and tumorigenesis. Nature. 2005 Sep 1;437(7055):147-53
• All: 2 reference(s)