Npm1tm2Ppp
Targeted Allele Detail
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Symbol: |
Npm1tm2Ppp |
Name: |
nucleophosmin 1; targeted mutation 2, Pier Paolo Pandolfi |
MGI ID: |
MGI:3604808 |
Synonyms: |
Npmhyp |
Gene: |
Npm1 Location: Chr11:33102287-33113206 bp, - strand Genetic Position: Chr11, 19.21 cM
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Alliance: |
Npm1tm2Ppp page
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Germline Transmission: |
Earliest citation of germline transmission:
J:101494
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Hypomorph) |
Mutation: |
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Insertion
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Mutation details: An Frt-flanked neomycin resistance cassette was inserted into intron 6. Mutant mice expressed protein at levels reduced to about 10-30% of wild-type levels. LoxP sites were inserted to flank exons 1 to 6, encompassing the inserted neo.
(J:101494)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S1/Sv * C57BL/6 | |
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Phenotypes: |
Affected Systems |
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cardiovascular system
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abnormal vitelline vasculature morphology
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cellular
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decreased fibroblast proliferation
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chromosome breakage
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embryo
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abnormal vitelline vasculature morphology
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decreased embryo size
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abnormal embryonic hematopoiesis
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growth/size/body
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decreased embryo size
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hematopoietic system
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abnormal embryonic hematopoiesis
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anemia
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integument
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pallor
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mortality/aging
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lethality throughout fetal growth and development, complete penetrance
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√
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nervous system
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√
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abnormal forebrain development
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√
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vision/eye
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√
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abnormal eye development
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Npm1 Mutation: |
36 strains or lines available
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Original: |
J:101494 Grisendi S, et al., Role of nucleophosmin in embryonic development and tumorigenesis. Nature. 2005 Sep 1;437(7055):147-53 |
All: |
2 reference(s) |
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