Vdr^tm1Tyam
Targeted Allele Detail

Summary

• Symbol: Vdr^tm1Tyam
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1, Takeyoshi Yamashita
• MGI ID: MGI:3604810
• Synonyms: VDR^-
• Gene: Vdr Location: Chr15:97752308-97806177 bp, - strand Genetic Position: Chr15, 53.85 cM
• Alliance: Vdr^tm1Tyam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101456
• Parent Cell Line: TT2F (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the 83 bp internal sequence of exon 2. RT-PCR of mutant bone and kidney failed to detect transcript. (J:101456)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdr Mutation: 36 strains or lines available

References

• Original: J:101456 Shimada T, et al., Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am J Physiol Renal Physiol. 2005 Nov;289(5):F1088-95
• All: 1 reference(s)