Efna3^tm1Rax
Targeted Allele Detail

Summary

• Symbol: Efna3^tm1Rax
• Name: ephrin A3; targeted mutation 1, Richard Axel
• MGI ID: MGI:3605006
• Gene: Efna3 Location: Chr3:89221206-89230272 bp, - strand Genetic Position: Chr3, 39.06 cM
• Alliance: Efna3^tm1Rax page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101720
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a neomycin resistance cassette. The splicing of exon 1 to 5 would result in a frameshift encoding a protein truncated after 45 amino acids, lacking 90% of the ectodomain. (J:101720)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efna3 Mutation: 10 strains or lines available

References

• Original: J:101720 Cutforth T, et al., Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map. Cell. 2003 Aug 8;114(3):311-22
• All: 13 reference(s)